My research interests are in statistical genetics and statistical methodology. Much of my work is motivated by scientific questions arising from human genetics and genomics studies.
My research interests are in statistical genetics and statistical methodology. Much of my work is motivated by scientific questions arising from human genetics and genomics studies.
Working Manuscripts
Zhang L, Paterson AD, Sun L. A general statistical framework for Hardy-Weinberg equilibrium inference on the X chromosome.
Viner C, Mastromatteo S, Denisko D, Negrea J, Tang Y, Zhang L, Hoffman M, Sun L. Ranking transcription factor binding motifs in ChIP-seq data without p-values.
Tang Y, Craiu RV, Sun L. General behaviour of p-values under the null and alternative.
Zhang L, Sun L. BLUE for Allele-Frequency Estimation under Hardy-Weinberg Disequilibrium.
Deng WQ, Paré G, Craiu RV, Sun L. Less is more: an unbiased and versatile estimator of genetic variance using summary statistics.
Garg E, Romain J, Sun L, Paterson AD. Assessing Hardy-Weinberg equilibrium in T2T-aligned 1000 Genomes Project. PLoS Genetics.
Fallahpour R, Sun L, Shi X, Stafford J, Tyrrell PN. An improved statistical framework for the HeTerogeneity Average (HTA) Index. Spatial Statistics.
Fallahpour R, Sun L, Shi X, Stafford J, Tyrrell PN. A tutorial review on heterogeneity measurement: theory and applications. Measurement.
Deng WQ, Craiu RV, Sun L. Perfect collinearity not created equal: measuring and visualizing the severity of multi-collinearity of modern omics data. Statistical Applications in Genetics and Molecular Biology.
Soave D, Hayalioglu M, Sun L. Winner's curse in rare variant analysis: effect size estimation bias depends on effect direction and the association method used. Frontiers in Genetics.
Lu TY, Manousaki D, Sun L, Paterson AD. Integrative proteogenomic analyses provide novel interpretations of type 1 diabetes risk loci through circulating proteins. Diabetes.
Zhang Z, Lawless J, Paterson AD, Sun L. Detecting latent gene-environment interaction when analyzing binary traits. PLoS Genetics.
Jiang Z, Sullivan PF, Li T, et al. The X chromosome's influences on the human brain. Science Advances.
Lu TY, Zhang W, Robinson-Cohen C, Engelman CD, Lu Q, de Boer IH, Sun L, Paterson AD. Characterization of gene-environment interactions for vitamin D through variance quantitative trait loci. American Journal of Clinical Nutrition.
Mendes M, Chen DZ, et al. Chromosome X-wide common variant association study in autism spectrum disorder. American Journal of Human Genetics.
Lin BX, Gong J, et al. Genome-wide association study of susceptibility to Pseudomonas aeruginosa infection in cystic fibrosis. European Respiratory Journal.
Kharaghani A, Tio E, Milic M, Bennett DA, De Jager PL, Schneider JA, Sun L, Felsky D. Association of whole-person polygenic component scores with Alzheimer's disease pathology. Human Molecular Genetics.
Wang Z, Paterson AD, Sun L. A population-aware retrospective regression to detect genome-wide variants with sex difference in allele frequency. Annals of Applied Statistics.
Lin BX, Paterson AD, Sun L. Better together against genetic heterogeneity: a sex-combined joint main and interaction analysis of 290 quantitative traits in the UK Biobank. PLoS Genetics.
Garg E, et al. Canadian COVID-19 host genetics cohort replicates known severity associations. PLoS Genetics.
Sugolov A, Emmenegger E, Paterson AD, Sun L. Statistical learning of large-scale genetic data. Statistics in Biosciences.
Zhao Y, Sun L. A stable and adaptive polygenic signal detection method based on repeated sample splitting. Canadian Journal of Statistics.
Chen DZ, Roshandel D, Wang Z, Sun L, Paterson AD. Comprehensive whole-genome analyses of the UK Biobank reveal significant sex differences in both genotype missingness and allele frequency on the X chromosome. Human Molecular Genetics.